2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (284):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-168702
    FLT3 ligand-2 950769-51-4
    FLT3 ligand-2 is a Ligand for Target Protein for PROTAC. FLT3 ligand-2 can be used to synthesize PROTAC FLT-3 degrader 1 (HY-114323).
    FLT3 ligand-2
  • HY-168202
    CCS1477a
    CCS1477a is the active form of the target protein ligand of PROTAC degrader MJP6412 (HY-168201).
    CCS1477a
  • HY-168387
    ITK ligand 1
    ITK ligand 1 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). ITK ligand 1 can be used in the synthesis of PROTACs (e.g. HY-149917).
    ITK ligand 1
  • HY-159956
    BTK-IN-39 2736510-62-4
    BTK-IN-39 (0204) is a PROTAC target protein ligand that can be used to synthesize PROTAC BTK Degrader-11 (HY-159947).
    BTK-IN-39
  • HY-162545
    HPK1-IN-47 2893885-42-0
    HPK1-IN-47 is a HPK1 ligand. HPK1-IN-47 can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-2 (HY-162544). HPK1-IN-47 can be used for research of HPK1-mediated diseases including cancer.
    HPK1-IN-47
  • HY-169361
    STAT3 ligand 5
    STAT3 ligand 5 is a ligand for STAT3, that can be used as target protein ligand for synthesis of PROTAC degrader SD-436 (HY-169360).
    STAT3 ligand 5
  • HY-170873
    G3BP1/2-Targeting ligand-1
    G3BP1/2-Targeting ligand-1 is the ligand for G3BP1/2 that can be used as target protein ligand for synthesis of G3BP1/2 PROTAC degrader PT-129 (HY-170872).
    G3BP1/2-Targeting ligand-1
  • HY-134724
    MTH1 ligand 1 2412986-35-5
    MTH1 ligand 1 is a target protein ligand for MTH1 and can be used to synthesize PROTAC aTAG 2139 (HY-161162).
    MTH1 ligand 1
  • HY-168311
    PROTAC IRAK4 ligand-5 2654056-24-1
    PROTAC IRAK4 ligand-5 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC IRAK4 ligand-5 can be utilized for the synthesis of KT-413 (HY-153368).
    PROTAC IRAK4 ligand-5
  • HY-134725
    MTH1 degrader-1 2412987-06-3
    MTH1 degrader-1, a MTH1 aTAG inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). MTH1 degrader-1 can be used for synthesis PROTAC aTAG 4531 (HY-163168).
    MTH1 degrader-1
  • HY-163921
    HDAC8-IN-11 3035977-24-0
    HDAC8-IN-11 is a ligand for target protein for pROTAC.
    HDAC8-IN-11
  • HY-168970
    MT2A ligand 1
    MT2A ligand 1 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC) targeting MT2A. MT2A ligand 1 can be used for synthesis AA-BR-157 (HY-168969).
    MT2A ligand 1
  • HY-168864
    POI ligand 1
    POI ligand 1 is a template for the non-selective HDAC inhibitor Vorinostat (HY-10221). POI ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC HDAC degraders with antitumor activity. POI ligand 1 can be used for the synthesis of FF2049 (HY-168863).
    POI ligand 1
  • HY-111855
    HG-7-85-01-Decyclopropane 2444044-44-2
    HG-7-85-01-Decyclopropane, the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
    HG-7-85-01-Decyclopropane
  • HY-168440
    Aurora-A ligand 1 2541626-73-5
    Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma.
    Aurora-A ligand 1
  • HY-168868
    RET ligand-2 3053537-08-6
    RET ligand-2 is a selective RET inhibitor. RET ligand-2 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC RET degraders with antitumor activity. RET ligand-2 can be used for the synthesis of RD-23 (HY-168867).
    RET ligand-2
  • HY-169487
    SMARCA2 ligand-12 2755762-94-6
    SMARCA2 ligand-12 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMARCA2 ligand-12 can be used for synthesis PROTAC SMARCA2 degrader-25 (HY-169276).
    SMARCA2 ligand-12
  • HY-111839
    ATRA-hydroxyimino 135325-47-2
    ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells.
    ATRA-hydroxyimino
  • HY-168036
    PIN1 inhibitor 3 3039570-04-9
    PIN1 inhibitor 3 (Compound A0) is a PIN1 inhibitor, with a KD of 25 nM and an IC50 of 150 nM. PIN1 inhibitor 3 can be used as a target protein ligand for the synthesis of PROTAC. PIN1 inhibitor 3 can be utilized in cancer research.
    PIN1 inhibitor 3
  • HY-161495
    CBP/p300 ligand 4
    CBP/p300 ligand 4 (Compound 4) is an orally active inhibitor for CBP/p300 bromodomain, with IC50 of 91.4 nM. CBP/p300 ligand 4 serves as a ligand for target protein XYD190 (HY-161495). XYD190 is a PROTAC degrader for CBP/p300.
    CBP/p300 ligand 4