2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (253):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-168036
    PIN1 inhibitor 3 3039570-04-9
    PIN1 inhibitor 3 (Compound A0) is a PIN1 inhibitor, with a KD of 25 nM and an IC50 of 150 nM. PIN1 inhibitor 3 can be used as a target protein ligand for the synthesis of PROTAC. PIN1 inhibitor 3 can be utilized in cancer research.
    PIN1 inhibitor 3
  • HY-161495
    CBP/p300 ligand 4
    CBP/p300 ligand 4 (Compound 4) is an orally active inhibitor for CBP/p300 bromodomain, with IC50 of 91.4 nM. CBP/p300 ligand 4 serves as a ligand for target protein XYD190 (HY-161495). XYD190 is a PROTAC degrader for CBP/p300.
    CBP/p300 ligand 4
  • HY-150885
    BTK ligand 1 330785-90-5
    BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk). BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies.
    BTK ligand 1
  • HY-161790
    Mpro ligand 1
    Mpro ligand 1 is the ligand for target protein for PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789). Mpro ligand 1 is the active form of Mpro ligand 2 (HY-161791).
    Mpro ligand 1
  • HY-159615
    Cbl-b-IN-21 2851878-87-8
    Cbl-b-IN-21 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Cbl-b-IN-21 can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608).
    Cbl-b-IN-21
  • HY-169152
    DCAF1 ligand 1 3036941-01-9
    DCAF1 ligand 1 (compound I-653) is the ligand for target protein for PROTAC BRD4-DCAF1 degrader-1 (HY-169151) which has a DC50 of 10~100 nM.
    DCAF1 ligand 1
  • HY-163949
    SMARCA2/4-IN-3
    SMARCA2/4-IN-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-3 can be used for synthesis PROTAC SMARCA2/4-degrader-19 (HY-163877).
    SMARCA2/4-IN-3
  • HY-49393
    BRD9 ligand-6 2460248-49-9
    BRD9 ligand-6 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-6 can be utilized for the synthesis of FHD-609 (HY-153367).
    BRD9 ligand-6
  • HY-168271
    ER ligand-2
    ER ligand-2 (Ligands for Target Protein for Compound 24) is the ligand of ER. ER ligand-2 can be used for synthesis PROTAC ER Degrader-11 (HY-168270).
    ER ligand-2
  • HY-161791
    Mpro ligand 2 2816967-14-1
    Mpro ligand 2 (Compound 8) is the ligand for target protein, which can be used for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789).
    Mpro ligand 2
  • HY-151069
    TMX-2039 2488892-01-7
    TMX-2039 is a pan-CDK inhibitor for both cell cycle CDKs (CDK1, CDK2, CDK4, CDK5 and CDK6) and transcriptional CDKs (CDK7 and CDK9), with IC50s of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5 and 25 nM, respectively. TMX-2039 acts as a Ligands for Target Protein for PROTACs.
    TMX-2039
  • HY-170354
    SMARCA2/4-ligand-4 3033592-40-1
    SMARCA2/4-ligand-4 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-4 can be used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347).
    SMARCA2/4-ligand-4
  • HY-170373
    RET ligand-1 3028787-16-5
    RET ligand-1 is a target protein ligand targeting RET that can be used to synthesize PROTAC LDD39 (HY-159967).
    RET ligand-1
  • HY-170303
    AR ligand-32 2505498-74-6
    AR ligand-32 is a target protein ligand, used for the synthesis of PROTAC AR Degrader-7 (HY-160221).
    AR ligand-32
  • HY-162876
    PROTAC BRD4 ligand-3 1445994-28-4
    PROTAC BRD4 ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC BRD4 ligand-3 can be used for synthesis PROTAC BRD4 Degrader-27 (HY-162875).
    PROTAC BRD4 ligand-3
  • HY-169235
    DHHC3 degrader 1
    DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232).
    DHHC3 degrader 1
  • HY-131178
    HG-7-85-01-NH2 1258391-29-5 99.20%
    HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
    HG-7-85-01-NH2
  • HY-162842
    HPK1-IN-51
    HPK1-IN-51 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). HPK1-IN-51 can be used for synthesis PROTAC PD-L1 degrader-2 (HY-162816).
    HPK1-IN-51
  • HY-168695
    BRD9 ligand-7
    BRD9 ligand-7 is a Ligand for Target Protein for PROTAC. CSI118 TFA can be used to synthesize BRD9 Degrader-1 (HY-156401).
    BRD9 ligand-7
  • HY-132942
    PROTAC BRD4 ligand-2 2154358-11-7
    PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718.
    PROTAC BRD4 ligand-2